Thursday, June 26, 2014
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Basigin Ok blood group (BSG;
meningitidis type IV pilus assembly protein (pilV);
meningitidis major pilin PilE (pilE)
Cell culture, mouse and ex
vivo tissue studies suggest blocking the interaction between pilin
subunits pilV or pilE and their receptor CD147 could help prevent or treat
meningococcal infections. In human endothelial cell cultures, CD147-specific
siRNAs or antibodies decreased adhesion of N. meningitidis compared
with control siRNA or antibodies. In mice grafted with human skin containing
functional blood vessels, N. meningitidis with pilV or pilE colonized
the human vasculature, whereas N. meningitidis lacking the pilin
subunits did not. In ex vivo human brain tissue, wild-type N.
meningitidis colonized CD147+ endothelial
cells, leptomeningeal cells and cortical brain vessels. Next steps include
identifying specific pilE and pilV epitopes that interact with CD147 to
develop targeted antibodies. SHX
Vaccines is financing the studies(see Managing
meningitis, page 10).
Published online June 26, 2014
Patented; licensed to SHX
Bernard, S.C. et al.
Nat. Med.; published online June 1, 2014; doi:10.1038/nm.3563
Contact: Sandrine Bourdoulous, Institut National de la Santé
et de la Recherche Médicale (INSERM), Paris, France
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