Indication

Target/marker/pathway

Summary

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Publication and contact information

Inflammation

Asthma

Chemokine CC motif ligand 20 (CCL20; MIP3A)

Mouse studies suggest the heparan sulfate-binding monosaccharide 2,4-O-disulfated iduronic acid (Di-S-IdoA) could help treat asthma. In a mouse model of antigen-induced asthma, knockout of the heparan sulfate synthase exostosin glycosyltransferase 1 (Ext1) decreased lymphocyte recruitment to the lungs and airway hyperresponsiveness compared with no alteration. Nasal inhalation or i.v. Di-S-IdoA, which blocks the interaction between heparan sulfate and CCL20, decreased T lymphocyte recruitment to the mouse lungs compared with saline. Next steps could include testing the monosaccharide in additional asthma models.

SciBX 7(24); doi:10.1038/scibx.2014.715
Published online June 19, 2014

Patent and licensing status unavailable

Nonaka, M. et al. Proc. Natl. Acad. Sci. USA; published online May 16, 2014;
doi:10.1073/pnas.1319870111
Contact: Minoru Fukuda, Sanford-Burnham Medical Research Institute, La Jolla, Calif.
e-mail:
minoru@sanfordburnham.org