Thursday, May 15, 2014
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Fibroblast growth factor 19 (FGF19);
growth factor receptor 4 (FGFR4;
Mouse studies suggest an
FGF19 variant that activates a subset of pathways downstream of FGFR4 could
help treat liver cancer. In mice, adeno-associated viral (AAV) vector-induced
expression of FGF19 variants showed that the M70 variant bound Fgfr4 but did
not induce tumor formation or activation of a tumor-associated signaling
pathway in liver cells. In mice, coexpression of FGF19 and the M70 variant
resulted in decreased tumor formation compared with expression of FGF19
alone, indicating that M70 can counter the known tumor-promoting activity of
wild-type FGF19. Next steps include evaluating M70 for clinical use in
primary biliary cirrhosis, hepatocellular carcinoma and nonalcoholic
Pharmaceuticals Inc. has ISIS-FGF4Rx,
an antisense oligonucleotide targeting FGFR4 mRNA, in Phase I testing
to treat obesity.
Medicines has BLU9931,
a small molecule inhibitor of FGFR4, in preclinical development to treat
Published online May 15, 2014
Patent applications filed;
available for licensing from NGM
Zhou, M. et al. Cancer
Res.; published online April 11, 2014;
Contact: Lei Ling, NGM Biopharmaceuticals Inc., South San
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