Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Breast cancer

MicroRNA-105 (miR-105)

Mouse studies suggest inhibiting miR-105 could help prevent breast cancer metastasis. In a mouse xenograft model of human breast cancer, overexpression of miR-105 increased metastasis to the lung and brain compared with normal expression. In xenograft mice bearing a breast cancer cell line with high miR-105 expression, an anti-miR-105 compound restored the integrity of the vascular barrier and decreased metastasis compared with a control compound. Next steps could include developing a therapeutic strategy based on the selective blockade of miR-105 signaling.

SciBX 7(19); doi:10.1038/scibx.2014.553
Published online May 15, 2014

Patent and licensing status unavailable

Zhou, W. et al. Cancer Cell; published online April 14, 2014;
doi:10.1016/j.ccr.2014.03.007
Contact: Shizhen Emily Wang, Beckman Research Institute at City of Hope, Duarte, Calif.
e-mail:

ewang@coh.org