Licensing status

Publication and contact information

Autoimmune disease

Autoimmune disease

Long noncoding RNA (lncRNA)

Cell-based studies suggest stimulating expression of a lncRNA found in dendritic cells (DCs) could help treat autoimmune diseases. In differentiating human DCs, shRNA targeting the DC-specific lncRNA encoded by the WDNM1-like pseudogene decreased antigen uptake and allogeneic CD4+ T cell proliferation compared with nontargeting shRNA. Biochemical analysis showed that the lncRNA specifically associated with and promoted the activity of signal transducer and activator of transcription 3 (STAT3), a key regulator of DC function. Next steps include determining whether the lncRNA levels are related to the outcome of immunological disorders.

SciBX 7(19); doi:10.1038/scibx.2014.548
Published online May 15, 2014

Patent application filed; licensing status unavailable

Wang, P. et al. Science; published online April 18, 2014;
Contact: Xuetao Cao, Second Military Medical University, Shanghai, China