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Autoimmune disease; infectious disease

Negative regulator of reactive oxygen species (NRROS)

In vitro and mouse studies suggest inhibiting NRROS could help treat infectious diseases and suggest enhancing its expression could help treat autoimmune diseases. In mice challenged with Listeria monocytogenes, Nrros knockout increased survival and decreased levels of bacteria in liver and spleen compared with no alteration. In a mouse model of autoimmune encephalomyelitis (EAE), bone marrow-specific Nrros deficiency resulted in increased disease severity and mortality compared with what was seen in nondeficient controls. Next steps include additional studies to elucidate the NRROS signaling pathway.

SciBX 7(18); doi:10.1038/scibx.2014.535
Published online May 8, 2014

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Noubade, R. et al. Nature; published online April 13, 2014;
Contact: Wenjun Ouyang, Genentech Inc., South
San Francisco, Calif.