Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Cancer

Ring finger protein 31 (RNF31; HOIP)

Cell culture studies suggest inhibiting the E3 ubiquitin ligase HOIP could increase cancer sensitivity to platinum-based chemotherapeutics such as cisplatin. In an siRNA screen using a human osteosarcoma cell line, HOIP was identified as a suppressor of cisplatin-induced cytotoxicity. In a panel of human cancer cell lines including those known to be cisplatin resistant, siRNA against HOIP increased sensitivity to cisplatin compared with control siRNA. Next steps include determining whether HOIP abundance or activity directly correlates with resistance to platinum-based therapy.

SciBX 7(18); doi:10.1038/scibx.2014.520
Published online May 8, 2014

Unpatented; licensing status undisclosed

MacKay, C. et al. Cancer Res.; published online March 31, 2014;
doi:10.1158/0008-5472.CAN-13-2131
Contact: Arno F. Alpi, University of Dundee, Dundee, U.K.
e-mail:

a.f.alpi@dundee.ac.uk