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Infectious disease


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In vitro studies suggest inducing an IgG3 response against HIV antigens could help create protective immunity against infection. In a clinical trial, Sanofi's ALVAC HIV vaccine and a bivalent clade B/E recombinant gp120 immunogen induced an antigen-specific IgG3 response and partial protective immunity, whereas another vaccination regimen that induced a weaker IgG3 response did not result in protective immunity. Next steps could include developing a vaccination strategy that induces a persistent IgG3 response.
ALVAC HIV is in Phase III testing.

SciBX 7(17); doi:10.1038/scibx.2014.496
Published online May 1, 2014

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Yates, N.L. et al. Sci. Transl. Med.; published online March 19, 2014;
Contact: Georgia D. Tomaras, Duke University, Durham, N.C.