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Pulmonary disease

Respiratory distress syndrome (RDS)

Ras homolog family member A (RHOA)

Cell culture and mouse studies suggest blocking nitration of RHOA could help treat acute lung injury (ALI) and RDS. In ALI and RDS, endothelial barrier function is compromised. In cultured endothelial cells, lipopolysaccharide (LPS) increased barrier disruption and RHOA activity compared with no treatment and resulted in the nitration of RHOA at Tyr34. In a mouse model of ALI, injection of a RHOA-derived peptide containing Tyr34 prior to injury blocked Rhoa nitration and decreased pathological changes compared with a control peptide injection. Next steps include developing additional peptides and determining whether they can reverse the disease course in additional mouse models of ALI.

SciBX 7(5); doi:10.1038/scibx.2014.151
Published online Feb. 6, 2014

Patent application filed; unavailable for licensing

Rafikov, R. et al. J. Biol. Chem.; published online Jan. 7, 2014;
Contact: Stephen M. Black, Georgia Regents University, Augusta, Ga.