Thursday, January 16, 2014
Publication and contact
Caspase recruitment domain family member 15
Mouse studies suggest
stimulating NOD2 could help treat atherosclerosis and periodontal bone loss.
In an apolipoprotein
knockout model of inflammation, deletion of Nod2 increased Porphyromonas
gingivalis-induced atherosclerosis, periodontal bone loss and
inflammatory serum cytokine levels compared with no Nod2 alteration.
In ApoE-/- mice, a NOD2 stimulator decreased serum cytokine
levels, atherosclerosis and bone loss compared with vehicle. Next steps could
include testing NOD2 stimulators in additional models of periodontal bone
loss and atherosclerosis.
Pharmaceutical Co. Ltd. markets the NOD2-targeting biologic
to treat bone cancer.
At least two other companies have NOD2-activating compounds in Phase I or
earlier development to treat cancer or infectious diseases.
Published online Jan. 16, 2014
Patent and licensing status
Yuan, H. et al. Proc.
Natl. Acad. Sci. USA; published online
Dec. 9, 2013;
Contact: Salomon Amar, Boston University, Boston, Mass.
Contact: Susan E. Leeman, same affiliation as above
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]