Thursday, January 16, 2014
Publication and contact
Caspase recruitment domain family member 15
Mouse studies suggest
stimulating NOD2 could help treat atherosclerosis and periodontal bone loss.
In an apolipoprotein
knockout model of inflammation, deletion of Nod2 increased Porphyromonas
gingivalis-induced atherosclerosis, periodontal bone loss and
inflammatory serum cytokine levels compared with no Nod2 alteration.
In ApoE-/- mice, a NOD2 stimulator decreased serum cytokine
levels, atherosclerosis and bone loss compared with vehicle. Next steps could
include testing NOD2 stimulators in additional models of periodontal bone
loss and atherosclerosis.
Pharmaceutical Co. Ltd. markets the NOD2-targeting biologic
to treat bone cancer.
At least two other companies have NOD2-activating compounds in Phase I or
earlier development to treat cancer or infectious diseases.
Published online Jan. 16, 2014
Patent and licensing status
Yuan, H. et al. Proc.
Natl. Acad. Sci. USA; published online
Dec. 9, 2013;
Contact: Salomon Amar, Boston University, Boston, Mass.
Contact: Susan E. Leeman, same affiliation as above
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