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Colon cancer

Fc fragment of IgG receptor transporter-a (FCGRT; FCRN)

Mouse studies suggest activating FCGRT on dendritic cells could help stimulate an immune response against colorectal cancers. In mouse models of colon cancer, Fcgrt knockout increased the number and size of tumors compared with no alteration. In tumors from Fcgrt knockout mice, the number of CD8+ T cells was lower than that in Fcgrt-expressing controls. In Fcgrt-deficient mice, adoptive transfer of T cells from tumors from Fcgrt-expressing mice decreased tumor load compared with transfer of cells from Fcgrt-deficient mice. Next steps could include testing the effects of FCGRT activation in a mouse model of colon cancer.

SciBX 7(2); doi:10.1038/scibx.2014.51
Published online Jan. 16, 2014

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Baker, K. et al. Immunity; published online Nov. 27, 2013;
Contact: Richard S. Blumberg, Brigham and Women's Hospital, Boston, Mass.