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Breast cancer

Cytochrome P450 family 27 subfamily A polypeptide 1 (CYP27A1)

Mouse studies suggest lowering cholesterol or inhibiting CYP27A1 could help treat estrogen-dependent breast cancer. In a mouse model of spontaneous, estrogen receptor-positive breast cancer, Cyp27a1-expressing mice fed a high-cholesterol diet showed greater intratumoral levels of 27-hydroxycholesterol, faster tumor growth and more metastases than Cyp27a1-deficient mice fed a high-cholesterol diet or Cyp27a1-expressing mice fed a control diet. In hypercholesterolemic mice with breast tumors, those fed a high-fat diet had greater levels of plasma 27-hydroxycholesterol and tumors that grew faster than mice fed a control diet or a high-fat diet and injected with a CYP27A1 inhibitor. Next steps include optimizing inhibitors of CYP27A1 and exploring new scaffolds.

SciBX 7(2); doi:10.1038/scibx.2014.46
Published online Jan. 16, 2014

Patent applications filed; available for licensing from the Duke University Office of Licensing & Ventures
Contact: Karthik Gopalakrisha, Duke University, Durham, N.C.
phone: 919-668-3401

Nelson, E.R. et al. Science; published online Nov. 29, 2013;
Contact: Donald P. McDonnell, Duke University School of Medicine, Durham, N.C.