Thursday, December 19, 2013
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Glucagon-like peptide-1 receptor (GLP-1R;
insulinotropic polypeptide receptor (GIP
Mouse studies suggest
peptides that agonize GLP1R, GCGR and GIP receptor could be used to treat obesity
and diabetes. In a mouse model of obesity with diabetes or in mice fed a
high-fat diet, a peptide that activated all three receptors decreased plasma glucose
levels and increased insulin levels after glucose challenge
compared with peptide hormones for individual receptors. In the high-fat diet-fed
model, the peptide induced weight loss and decreased overall glucose exposure
compared with saline. Next steps could include optimizing the pharmacology of
At least six companies market agonists for GLP1R and GCGR to treat
cardiovascular or endocrine/metabolic disease.
Published online Dec. 19, 2013
Patent and licensing status
Gault, V.A. et al. J.
published online Oct. 28, 2013;
Contact: Nigel Irwin, University of Ulster, Londonderry,
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