This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Endocrine/metabolic disease

Diabetes

Serotonin
(5-HT2C) receptor

Mouse studies suggest agonizing the 5-HT2C receptor on proopiomelanocortin (POMC) neurons could help treat diabetes. In mice, knockout of the gene encoding the 5-HT2C receptor specifically in POMC neurons increased diet-induced obesity, blood glucose levels and glucagon levels compared with no alteration and led to hyperinsulinemia. Conditional knockout of the gene in POMC neurons in adult mice caused the same changes in metabolic activity. Next steps include developing a 5-HT2C receptor agonist that acts specifically on the neuronal subtype.

SciBX 6(47); doi:10.1038/scibx.2013.1352
Published online Dec. 12, 2013

Unpatented; unavailable for licensing

Berglund, E.D. et al. J. Clin. Invest.; published online Nov. 1, 2013;
doi:10.1172/JCI70338
Contact: Joel K. Elmquist, The University of Texas Southwestern Medical Center, Dallas, Texas
e-mail:
joel.elmquist@utsouthwestern.edu

Contact: Yong Xu, Baylor College of Medicine, Houston, Texas
e-mail:
yongx@bcm.edu