Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Cancer

Tubulin

In vitro and mouse studies have identified aryloxazole-based tubulin inhibitors that could help treat cancer. Screening of a small molecule library and in vitro testing of aryloxazole analogs identified several lead compounds that inhibited tubulin polymerization and reduced the viability of human leukemia, lung cancer and colorectal cancer cell lines at nanomolar IC50 values. In mice bearing xenograft colorectal tumors, one lead compound decreased tumor growth compared with no treatment. Future studies could include optimizing and testing the lead compounds in other tumor models.

SciBX 6(46); doi:10.1038/scibx.2013.1315
Published online Dec. 5, 2013

Patent and licensing status unavailable

Choi, M.J. et al. J. Med. Chem.; published online Oct. 27, 2013;
doi:10.1021/jm400840p
Contact: GhilSoo Nam, Korea Institute of Science and Technology, Seoul, South Korea
e-mail:

gsnam@kist.re.kr
Contact: Ae Nim Pae, same affiliation as above
e-mail:

anpae@kist.re.kr