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Infectious disease


Mycobacterium tuberculosis transmembrane transport protein 3 (mmpL3)

In vitro and mouse studies identified indol-2-carboxamides that could help treat tuberculosis. In vitro, two carboxamide analogs with indol and cyclohexyl ring modifications had activity against M. tuberculosis but not human monocytes or hepatocytes. In mice, the two compounds decreased
M. tuberculosis colony formation in the lung compared with no treatment or the generic compound ethambutol. Next steps could include further optimization of the compounds for potency and solubility and publication of further details of how the compounds inhibit their proposed target, mmpL3.

SciBX 6(43); doi:10.1038/scibx.2013.1228
Published online Nov. 7, 2013

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Kondreddi, R.R. et al. J. Med. Chem.; published online Oct. 3, 2013;
Contact: Ravinder Reddy Kondreddi, Novartis Institute for Tropical Diseases, Chromos, Singapore