This week in therapeutics




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Breast cancer

G protein-coupled receptor 116 (GPR116)

Cell culture and mouse studies suggest antagonizing GPR116 could be useful for treating metastatic breast cancer. In cell culture, small interfering RNA knockdown of GPR116 decreased invasion compared with no knockdown. In a mouse model of breast cancer metastasis, siRNA knockdown of GPR116 decreased bone and lung metastasis and increased survival compared with no knockdown. Next steps could include identifying selective inhibitors of GPR116 and testing them in mouse models of breast cancer.

SciBX 6(41); doi:10.1038/scibx.2013.1157
Published online Oct. 24, 2013

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Tang, X. et al. Cancer Res.; published online Sept. 5, 2013;
Contact: Jian Luo, East China Normal University, Shanghai, China