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Skin cancer

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In vitro and mouse studies suggest treating skin inflammation could help treat or prevent skin squamous cell carcinoma (SCC). In mice, inducible overexpression of c-fos in keratinocytes led to recruitment of CD4+ T cells, inflammation and development of preneoplastic lesions. In this mouse model, a topical carcinogen accelerated development of invasive SCCs. In this mouse model, the generic anti-inflammatory drug sulindac decreased tumor size and frequency compared with no treatment. Next steps could include testing anti-inflammatory agents in models of established SCC.

SciBX 6(39); doi:10.1038/scibx.2013.1095
Published online Oct. 10, 2013

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Briso, E.M. et al. Genes Dev.; published online Sept. 12, 2013;
Contact: Erwin F. Wagner, Spanish National Cancer Research Center (CNIO), Madrid, Spain