Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Skin cancer

Not applicable

In vitro and mouse studies suggest treating skin inflammation could help treat or prevent skin squamous cell carcinoma (SCC). In mice, inducible overexpression of c-fos in keratinocytes led to recruitment of CD4+ T cells, inflammation and development of preneoplastic lesions. In this mouse model, a topical carcinogen accelerated development of invasive SCCs. In this mouse model, the generic anti-inflammatory drug sulindac decreased tumor size and frequency compared with no treatment. Next steps could include testing anti-inflammatory agents in models of established SCC.

SciBX 6(39); doi:10.1038/scibx.2013.1095
Published online Oct. 10, 2013

Patent and licensing status unavailable

Briso, E.M. et al. Genes Dev.; published online Sept. 12, 2013;
doi:10.1101/gad.223339.113
Contact: Erwin F. Wagner, Spanish National Cancer Research Center (CNIO), Madrid, Spain
e-mail:

ewagner@cnio.es