Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Autoimmune disease

Multiple sclerosis (MS)

IL-27

Studies in cell culture and mice suggest IL-27-conditioned dendritic cells (DCs) could help treat MS. In cell culture, DCs treated with the anti-inflammatory cytokine IL-27 had lower antigen presentation and autoimmunity-associated activity than DCs treated with vehicle. In a mouse model of MS, transfusion of IL-27-treated DCs decreased inflammatory cytokine levels in the brain and slowed disease progression compared with transfusion of vehicle-treated DCs. Next steps include validating the findings in human DCs.

SciBX 6(38); doi:10.1038/scibx.2013.1053
Published online Oct. 3, 2013

Patent pending; available for licensing

Mascanfroni, I.D. et al. Nat. Immunol.; published online Sept. 1, 2013;
doi:10.1038/ni.2695
Contact: Francisco J. Quintana, Harvard Medical School, Boston, Mass.
e-mail:
fquintana@rics.bwh.harvard.edu