Thursday, September 26, 2013
This week in therapeutics
Publication and contact
Myocardial infarction (MI)
CD20; chemokine CC motif ligand 7 (CCL7;
Human serum and mouse
studies suggest antibodies against CD20 could help treat MI. In mouse models
of MI, B cells and monocytes in cardiac tissue and levels of Ccl7 secreted by
B cells in blood and cardiac tissue were higher than those in healthy
controls. In these models, an anti-Cd20 mAb decreased Ccl7 levels and infarct
size and increased cardiac function compared with vehicle. In serum from
patients with MI, CCL7 levels were associated with risk of death and
recurrent MI. Planned work includes testing anti-CD20 antibodies in patients
an antibody against CD20 from Biogen
Idec Inc. and the Genentech
Inc. unit of Roche,
is marketed for a variety of autoimmune diseases and hematological cancers.
a mAb against CD20 from Genmab
A/S and GlaxoSmithKline
plc, is marketed for chronic lymphocytic leukemia (CLL; see
therapy for heart attack, page 1).
Published online Sept. 26, 2013
Patent application filed by
National de la Santé et de la Recherche Médicale (INSERM)
of Cambridge; available for licensing
Zouggari, Y. et al. Nat.
Med.; published online Sept. 15, 2013;
Contact: Ziad Mallat, Institut National de la Santé et de la
Recherche Médicale (INSERM), Paris, France
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