This week in therapeutics




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Skin cancer

Myeloid-lymphoid or mixed-lineage leukemia translocated to 6 (MLLT6); histone methyltransferase DOT1L (DOT1L); b-catenin (CTNNB1)

Mouse studies suggest inhibiting MLLT6 or CTNNB1 could help treat squamous cell carcinoma. In a mouse xenograft model of squamous cell carcinoma, inducible small hairpin RNAs against Mllt6 or Ctnnb1 increased tumor-free survival compared with inducible control shRNA. Next steps could include determining if inhibiting DOT1L, which is associated with MLL proteins, could have a functional role in squamous cell carcinomas.

SciBX 6(35); doi:10.1038/scibx.2013.960
Published online Sept. 12, 2013

Unpatented; licensing status not applicable

Beronja, S. et al. Nature; published online Aug. 14, 2013;
Contact: Elaine Fuchs, The Rockefeller University, New York, N.Y.