This week in therapeutics




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Regulatory associated protein of MTOR complex 1 (RPTOR; raptor); sperm-associated antigen 5 (SPAG5; astrin)

In vitro studies suggest inhibiting the interaction between astrin and raptor could help treat cancer. In a human cervical cancer cell line, astrin interacted with raptor to block its interaction with mammalian target of rapamycin (mTOR; FRAP; RAFT1). In this cell line, small interfering RNA against astrin increased the signaling required for cellular stress-induced apoptosis compared with control siRNA. In breast cancer cells, siRNAs against astrin increased oxidative stress-induced apoptosis. Next steps include identifying or developing pharmacological inhibitors of the astrin-raptor interaction.

SciBX 6(35); doi:10.1038/scibx.2013.956
Published online Sept. 12, 2013

Patent application filed; available for licensing

Thedieck, K. et al. Cell; published online Aug. 15, 2013;
Contact: Kathrin Thedieck, University of Freiburg, Freiburg, Germany