Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Cervical cancer

Histone deacetylase 10 (HDAC10)

Patient tissue and mouse studies suggest increasing HDAC10 activity could help prevent cervical cancer metastasis. In an analysis of clinical and microarray data in 60 cervical cancer samples, decreased HDAC10 protein levels correlated with increased lymph node metastasis and more advanced disease. In a mouse xenograft model of human cervical cancer, HDAC10 overexpression decreased metastasis compared with normal HDAC10 expression, though it did not inhibit tumor growth. Next steps include determining whether the antimetastatic effects of HDAC10 apply to other cancers.

SciBX 6(34); doi:10.1038/scibx.2013.925
Published online Sept. 5, 2013

Unpatented; licensing status not applicable

Song, C. et al. J. Biol. Chem.; published online July 29, 2013;
doi:10.1074/jbc.M113.498758
Contact: Jiuhong Kang,
Tongji University, Shanghai, China
e-mail:
jhkang@tongji.edu.cn
Contact: Chuanyue Wu, University of Pittsburgh, Pittsburgh, Pa.
e-mail:
carywu@pitt.edu