This week in therapeutics




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Rat studies suggest decreasing mitochondrial reactive oxygen species could help prevent kidney damage in acute infectious pyelonephritis. In a rat model of acute pyelonephritis, a mitochondria-targeted plastoquinone antioxidant called SkQR1 decreased kidney pathology and increased survival compared with no treatment. In this model, SkQR1 pretreatment prevented an increase in leukocyte numbers and leukocyte-produced reactive oxygen species. Next steps include additional preclinical studies to evaluate the plastoquinone antioxidant in additional nephrological and urological pathologies.
Mitotech LLC has mitochondria-targeted antioxidants, including SkQR1, in preclinical development.

SciBX 6(33); doi:10.1038/scibx.2013.894
Published online Aug. 29, 2013

SkQR1 and related molecules covered by issued and filed patents; licensing details available from Mitotech
Contact: Maxim Skulachev, Mitotech LLC, Moscow, Russia

Plotnikov, E.Y. et al. Proc. Natl. Acad. Sci. USA; published online
July 29, 2013;
Contact: Dmitry B. Zorov, Lomonosov Moscow State University,
Moscow, Russia