This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Cancer

Lysyl oxidase (LOX)

Mouse studies suggest inhibiting LOX in the tumor stroma could help prevent metastasis. LOX modifies the extracellular matrix and tumor microenvironment. In a genetic mouse model of highly metastatic breast cancer, chemical inhibition of Lox, which is expressed by stromal fibroblasts, decreased lung metastases compared with no inhibition. In culture, transforming growth factor-b (Tgfb; Tgfb) from myeloid cells, which is known to promote metastasis, increased Lox expression on fibroblasts. Next steps include designing and testing LOX-neutralizing antibodies for cancer.

SciBX 6(32); doi:10.1038/scibx.2013.853
Published online Aug. 22, 2013

Unpatented; licensing status not applicable

Pickup, M.W. et al. Cancer Res.; published online July 15, 2013;
doi:10.1158/0008-5472.CAN-13-0012
Contact: Harold L. Moses, Vanderbilt University, Nashville, Tenn.
e-mail:
hal.moses@vanderbilt.edu