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Endocrine/metabolic disease

Obesity; metabolic syndrome

Complement component 1q subcomponent (C1Q); complement component 1q subcomponent A chain (C1QA)

Mouse studies suggest inhibiting C1Q signaling could help prevent obesity-associated metabolic impairments and metabolic syndrome. In women who were obese and in mice fed a high-fat diet, complement-factor activation in adipose tissue was increased compared with lean controls. In mice, C1qa deficiency prevented high-fat diet−induced impairments in glucose homeostasis and decreased both hepatic steatosis and insulin resistance compared with no C1qa deficiency. Next steps could include developing C1QA-specific inhibitors and evaluating them in obesity models.

SciBX 6(31); doi:10.1038/scibx.2013.827
Published online Aug. 15, 2013

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Hillian, A.D. et al. J. Biol. Chem.; published online June 20, 2013;
Contact: Laura Nagy, Cleveland Clinic Cleveland, Ohio