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Colorectal cancer; colitis

c-Src tyrosine kinase (CSK)

Mouse studies suggest activating CSK could help treat colitis and colon cancer. In a mouse model for chemical-induced colitis and colon cancer, a diet including the plant flavonoid isorhamnetin resolved colitis and decreased tumor burden and increased survival compared with a control diet. In colorectal cancer cells, isorhamnetin activity was dependent on increased CSK expression and signaling. Next steps could include identifying the molecular target of isorhamnetin and testing the compound in additional colon cancer models.

SciBX 6(30); doi:10.1038/scibx.2013.802
Published online Aug. 8, 2013

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Saud, S.M. et al. Cancer Res.;
published online July 1, 2013;
Contact: Matthew R. Young, National Cancer Institute, Frederick, Md.