Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Leukemia

Tet methylcytosine dioxygenase 1 (TET1)

Studies in patient samples and in mice suggest inhibiting TET1 could help treat mixed lineage leukemia (MLL). In MLL patient samples, TET1 expression was greater than that in samples from normal controls. In a mouse xenograft model for MLL, small hairpin RNA against Tet1 delayed leukemia growth and increased survival compared with control shRNA. Next steps include screening for small molecule inhibitors of TET1.

SciBX 6(30); doi:10.1038/scibx.2013.788
Published online Aug. 8, 2013

Patent and licensing status undisclosed

Huang, H. et al. Proc. Natl. Acad. Sci. USA; published online July 1, 2013;
doi:10.1073/pnas.1310656110
Contact: Jianjun Chen, The University of Chicago, Chicago, Ill.
e-mail:
jchen@medicine.bsd.uchicago.edu
Contact: Janet D. Rowley, same affiliation as above
e-mail:
jrowley@bsd.uchicago.edu