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Liver cancer

Deoxycholic acid

Mouse studies suggest decreasing deoxycholic acid production or deoxycholic acid-producing bacteria in the gut could help prevent obesity-associated hepatocellular carcinoma (HCC). In obese, HCC-prone mice, vancomycin decreased both serum levels of deoxycholic acid and tumor burden in the liver compared with vehicle control. Pharmacological inhibition of deoxycholic acid production also led to decreased tumor burden in the liver. Next steps include determining whether levels of deoxycholic acid or deoxycholic acid-producing bacteria could be used as biomarkers in obesity-associated cancer (see Connecting the microbiome to obesity-associated cancers, page 1).

SciBX 6(29); doi:10.1038/scibx.2013.755
Published online Aug. 1, 2013

Patent application filed; available for licensing and partnering

Yoshimoto, S. et al. Nature; published online June 26, 2013;
Contact: Eiji Hara, Japanese Foundation for Cancer Research, Tokyo, Japan