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Infectious disease

Bacterial infection


Cell culture studies suggest anthracimycin derivatives could help treat bacterial infections. In bacterial cell culture, anthracimycin inhibited the growth of Gram-positive bacteria, including Bacillus anthracis and methicillin-resistant Staphylococcus aureus (MRSA), but showed little or no activity against Gram-negative bacteria. In culture, a derivative of anthracimycin inhibited the growth of both Gram-positive and Gram-negative bacteria. Next steps include developing more drug-like derivatives of anthracimycin and testing them in mouse models for MRSA infection.

SciBX 6(28); doi:10.1038/scibx.2013.724
Published online July 25, 2013

Unpatented; licensing status not applicable

Jang, K.H. et al. Angew. Chem. Int. Ed.; published online June 17, 2013;
Contact: William Fenical, University of California, San Diego, La Jolla, Calif.