Licensing status

Publication and contact information

Infectious disease

Bacterial infection

HBV core protein

In vitro and mouse studies suggest the arginine-rich domain of HBV core protein could help treat bacterial infections. In various Gram-positive and Gram-negative bacteria including multidrug-resistant strains, the HBV core protein arginine-rich domain had antimicrobial activity. In a mouse model for Staphylococcus aureus-induced sepsis, early intraperitoneal treatment with peptides based on the domain decreased bacterial burden by 100-fold compared with saline treatment and prevented death in all cases. Next steps include testing the peptides in additional infection models.

SciBX 6(28); doi:10.1038/scibx.2013.722
Published online July 25, 2013

Patent and licensing status unavailable

Chen, H.-L. et al. PLoS Pathog.;
published online June 13, 2013;
Contact: Chiaho Shih, Academia Sinica, Taipei, Taiwan