Licensing status

Publication and contact information

Infectious disease

Bacterial infection


In vitro studies identified small molecule inhibitors of trans-translation that could help treat bacterial infections. Trans-translation, a process that uses transfer-messenger RNA (tmRNA) to repair stalled ribosomal complexes, is required for bacterial survival against stress. A high throughput screen of 663,000 compounds in Escherichia coli identified multiple lead small molecules that inhibited trans-translation. In vitro, the compounds inhibited the growth of multiple strains of pathogenic bacteria at low micromolar concentrations. Next steps include identifying the mechanism of action for the lead compounds and developing more potent derivatives.

SciBX 6(26); doi:10.1038/scibx.2013.656
Published online July 11, 2013

Patent applications filed covering compounds with increased potency; available for licensing

Ramadoss, N.S. et al. Proc. Natl. Acad. Sci. USA; published online June 3, 2013;
Contact: Kenneth C. Keiler, Pennsylvania State University, University Park, Pa.