Thursday, June 20, 2013
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Leukotriene B4 (LTB4); complement 5 (C5)
mouse studies suggest inhibitors of both C5 and LTB4 could help treat
inflammatory diseases. In vitro, the tick-derived protein Ornithodoros
moubata complement inhibitor (OmCI)
bound both LTB4 and C5 and blocked their activation. In a mouse model for
antigen-induced acute lung injury, OmCI decreased neutrophil recruitment and
damage to pulmonary microvasculature compared with inhibition of Ltb4 or C5
alone. Next steps could include testing OmCI in additional animal models for
Cellceutix Corp.'s Kevetrin thioureidobutyronitrile,
an LTB4 and protein kinase B (PKB; PKBA;
AKT; AKT1) inhibitor, is in
Phase I testing to treat solid tumors.
Alexion Pharmaceuticals Inc.
markets Soliris eculizumab, a
humanized mAb targeting C5, to treat hemolytic uremic syndrome and paroxysmal
At least seven other companies have C5 inhibitors in Phase II testing or
earlier to treat various indications.
Published online June 20, 2013
Patent and licensing status
Roversi, P. et al. J.
Biol. Chem.; published online April 26, 2013;
Contact: Miles A. Nunn, Centre for Ecology and Hydrology,
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