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Cardiovascular disease

Ischemia/reperfusion injury

Complement component 3a
receptor 1
(C3AR1; C3AR)

Mouse studies suggest C3AR agonists could help treat ischemia/reperfusion injury. In mice, C3ar knockout increased neutrophil-mediated damage in response to ischemia/reperfusion injury compared with no knockout. In a mouse model for intestinal ischemia/reperfusion injury, a C3AR agonist decreased circulating neutrophil numbers and intestinal tissue damage compared with vehicle. Next steps include lead optimization of candidate compounds and IND-enabling studies.

SciBX 6(24); doi:10.1038/scibx.2013.599
Published online June 20, 2013

Patented by The University of Queensland; available for licensing

Wu, M.C.L. et al. Proc. Natl. Acad. Sci. USA; published online
May 21, 2013;
Contact: Trent M. Woodruff, The University of Queensland, Brisbane, Queensland, Australia