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Cardiovascular disease


homolog 1

Cell culture studies suggest inhibiting DKK1 could help treat atherosclerosis. Endothelial-to-mesenchymal transition contributes to calcification and fibrosis in atherosclerosis. In primary bovine aortic endothelial cells, mouse Dkk1 induced endothelial-to-mesenchymal morphology and phenotype. In a bovine cell model for atherosclerosis, Dkk1 increased calcium deposition and collagen accumulation compared with vehicle. Ongoing work includes evaluating the effect of Dkk1 deficiency in mouse models for atherosclerosis.
Novartis AG and MorphoSys AG have BHQ880, a HuCAL neutralizing antibody against DKK1, in Phase II testing to treat multiple myeloma (MM).

SciBX 6(24); doi:10.1038/scibx.2013.598
Published online June 20, 2013

Unpatented; licensing status not applicable

Cheng, S.-L. et al. Arterioscler. Thromb. Vasc. Biol.; published online
May 16, 2013;
Contact: Dwight A. Towler, Sanford-Burnham Medical Research Institute at Lake Nona, Orlando, Fla.