Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Cancer

Thrombospondin-1 (TSP-1; THBS1); prosaposin (PSAP)

Cell-based and mouse studies suggest increasing TSP-1 expression could help treat metastatic cancer. In a Tsp-1-/- mouse xenograft model for metastatic cancer, transplant of Tsp-1-secreting bone marrow cells decreased metastasis compared with transplant of Tsp-1-deficient cells. Injection of a pentapeptide derived from PSAP, a protein that induces expression of Tsp-1, decreased metastasis compared with a control peptide. Next steps include mining additional components of the Tsp-1 pathway for therapeutic targets.

SciBX 6(22); doi:10.1038/scibx.2013.542
Published online June 6, 2013

Patented; available for licensing

Catena, R. et al. Cancer Discov.; published online April 30, 2013;
doi:10.1158/2159-8290.CD-12-0476
Contact: Vivek Mittal, Weill Cornell Medical College, New York, N.Y.
e-mail:
vim2010@med.cornell.edu
Contact: Randolph S. Watnick, Harvard Medical School, Boston, Mass.
e-mail:
randy.watnick@childrens.harvard.edu