This week in therapeutics




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Breast cancer

Discoidin domain receptor tyrosine kinase 2 (DDR2)

In vitro and mouse studies suggest inhibiting DDR2 could help treat metastatic breast cancer. In primary invasive breast tumors, DDR2 expression was greater than that in normal breast tissue and correlated with reduced survival. In a human breast cancer cell line, small hairpin RNA against DDR2 decreased invasion and migration compared with a scrambled control shRNA. In normal mice, implantation of a mouse breast cancer cell line pretreated with shRNA against Ddr2 decreased the number and size of lung metastases compared with implantation of cells pretreated with a scrambled control shRNA. Ongoing work includes a computational screen that identifies small molecule DDR2 inhibitors.

SciBX 6(19); doi:10.1038/scibx.2013.461
Published online May 16, 2013

Unpatented; available for licensing or partnering

Zhang, K. et al. Nat. Cell Biol.; published online May 5, 2013;
Contact: Gregory D. Longmore, Washington University in
St. Louis, St. Louis, Mo.