Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Endocrine/metabolic disease

Diabetes

Betatrophin

Mouse studies suggest betatrophin could be useful for treating type 2 diabetes. In three mouse models for
type 2 diabetes, betatrophin injection increased blood glucose levels and islet b cell mass compared with vehicle. Next steps include identification of the betatrophin receptor and preclinical development of a recombinant injectable form of the protein.
Evotec AG and Johnson & Johnson's Janssen Pharmaceuticals Inc. unit have a program based on the technology in the lead optimization stage for type 2 diabetes.

SciBX 6(18); doi:10.1038/scibx.2013.439
Published online May 9, 2013

Patent pending; licensed to Evotec

Yi, P. et al. Cell; published online
April 25, 2013;
doi:10.1016/j.cell.2013.04.008
Contact: Douglas A. Melton, Harvard University, Cambridge, Mass.
e-mail:

dmelton@harvard.edu