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Brain cancer

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In vitro and mouse studies suggest inhibiting hypoxic exosomes could help treat brain cancer. Hypoxia-associated proteins that contributed to tumor pathology were present in exosomes isolated from patients with glioblastoma multiforme (GBM) but not in those from healthy controls. In mouse xenograft models for human GBM, hypoxic exosomes were associated with faster tumor expansion, increased tumor vasculature and greater tumor volume compared with normoxic exosomes. Next steps could include identifying specific mediators of hypoxic signaling within exosomes and evaluating their potential as drug targets.

SciBX 6(18); doi:10.1038/scibx.2013.434
Published online May 9, 2013

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Kucharzewska, P. et al. Proc. Natl. Acad. Sci. USA; published online April 15, 2013;
Contact: Mattias Belting, Lund University, Lund, Sweden