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Musculoskeletal disease

Muscular dystrophy

Dual specificity phosphatase 10 (DUSP10; MKP5)

Mouse studies suggest inhibiting MKP5 could help treat Duchenne muscular dystrophy (DMD). In mice, Mkp5 knockout increased skeletal muscle mass and regenerative myogenesis compared with no knockout. In the mdx mouse model for DMD, Mkp5-deficient mice had better skeletal muscle morphology and decreased muscle degeneration compared with nondeficient controls. Next steps could include screening for small molecule inhibitors of MKP5.

SciBX 6(15); doi:10.1038/scibx.2013.368
Published online April 18, 2013

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Shi, H. et al. J. Clin. Invest.; published online April 1, 2013;
Contact: Anton M. Bennett, Yale School of Medicine, New Haven, Conn.