Thursday, March 28, 2013
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Sirtuin 1 (SIRT1)
In vitro and mouse studies suggest inhibiting SIRT1
specifically in neurons could help treat type 2 diabetes. Prior studies have
suggested that peripheral SIRT1 activation could help treat the disease, but
results have been inconsistent. In mice, neuron-specific knockout of Sirt1
sensitivity and glucose tolerance compared with no
knockout. Next steps could include identifying strategies to prevent
peripherally acting SIRT1 activators from accessing the CNS.
Elixir Pharmaceuticals Inc.'s
EX-527, an oral SIRT1
inhibitor, is in Phase II testing to treat Huntington's disease (HD).
GlaxoSmithKline plc's GSK2245840 SIRT1 activator
is in Phase II testing to treat psoriasis. The compound completed Phase I/II
trials for type 2 diabetes, but the pharma said it is no longer pursuing that
indication with the compound.
Ildong Pharmaceutical Co. Ltd.'s
SIRT1 activator, ID2244, is in preclinical
development to treat metabolic syndrome.
Published online March 28, 2013
available for partnerships
Lu, M. et al. J. Biol.
Chem.; published online March 1, 2013;
Contact: Jerrold M. Olefsky, University of California, San
Diego, La Jolla, Calif.
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