This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Cancer

IL-11

Mouse and cell culture studies suggest inhibiting
IL-11 signaling could help treat hypoxic solid tumors. Human colorectal cancer cells cultured under hypoxic conditions had greater IL-11 mRNA levels and anchorage-independent growth than cells cultured under normal oxygen conditions. In a mouse xenograft model for human prostate cancer, small hairpin RNA against IL-11 decreased tumor growth compared with scrambled shRNA. Next steps could include evaluating the combination of IL-11 signaling inhibitors with other cancer therapeutics.

SciBX 6(11); doi:10.1038/scibx.2013.258
Published online March 21, 2013

Unpatented; licensing not applicable

Onnis, B. et al. J. Clin. Invest.; published online March 15, 2013;
doi:10.1172/JCI59623
Contact: Giovanni Melillo, Bristol-Myers Squibb, Princeton, N.J.
e-mail:
giovanni.melillo@bms.com

Contact: Annamaria Rapisarda, SAIC-Frederick Inc., Frederick, Md.
e-mail:
rapisardaa@mail.nih.gov