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Colorectal cancer

Jagged 1 (JAG1)

Cell culture studies suggest blocking soluble JAG1 could help treat colorectal cancer by targeting cancer stem cells. In human colorectal cancer cell lines incubated in endothelial cell-conditioned medium, antibody-mediated depletion of soluble JAG1 decreased the formation of cells with a cancer stem cell phenotype compared with no depletion. Next steps could include evaluating JAG1-targeting antibodies in combination with existing therapies in mouse models of colorectal cancer.

SciBX 6(8); doi:10.1038/scibx.2013.192
Published online Feb. 28, 2013

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Lu, J. et al. Cancer Cell; published online Jan. 31, 2013;
Contact: Lee M. Ellis, The University of Texas MD Anderson Cancer Center, Houston, Texas