Thursday, February 21, 2013
This week in therapeutics
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growth factor receptor 3 (EGFR3;
Cell culture and mouse
studies suggest Zelboraf
could be used to treat BRAF-mutant thyroid cancer. In a thyroid cancer cell
line, vemurafenib activated HER3, which could be blocked with lapatinib. In
three BRAF-mutant thyroid cancer cell lines, vemurafenib plus lapatinib
decreased cellular proliferation compared with either drug alone. In a
genetic mouse model of thyroid tumorigenesis, combined treatment with the two
drugs decreased tumor volume compared with either drug alone. Ongoing work
includes clinical testing of the combination in individuals with metastatic
Sankyo Co. Ltd., Chugai
Pharmaceutical Co. Ltd. and Roche
market Zelboraf, an oral small molecule inhibitor of oncogenic BRAF V600E, to
treat melanoma. The drug is in Phase II testing for thyroid cancer.
plc markets Tykerb, a HER1
receptor kinase inhibitor, to treat breast cancer.
Published online Feb. 21, 2013
status not applicable
Montero-Conde, C. et al.
Cancer Discov.; published online Jan. 29, 2013;
Contact: James A. Fagin, Memorial Sloan-Kettering Cancer
New York, N.Y.
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