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Genitourinary disease

Benign prostatic hyperplasia (BPH)

Gastrin-releasing peptide (GRP)

In vitro and rat studies suggest GRP antagonists could help treat BPH. In human prostate cell lines, a GRP antagonist decreased cell proliferation compared with no treatment. In rat models of testosterone-induced BPH, the GRP antagonist decreased prostate size and inflammatory markers compared with no treatment. Next steps could include studying GRP antagonists in additional animal models of BPH.

SciBX 6(6); doi:10.1038/scibx.2013.140
Published online Feb. 14, 2013

Findings unpatented; licensing status not applicable

Rick, F.G. et al. Proc. Natl. Acad. Sci. USA; published online Jan. 28, 2013;
Contact: Andrew V. Schally, Veterans Affairs Medical Center and University of Miami Miller School of Medicine, Miami, Fla.
Contact: Ferenc G. Rick, Veterans Affairs Medical Center, Miami, Fla.