Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Endocrine/metabolic disease

Diabetes

Unknown

Cell culture and mouse studies suggest a diarylurea-based compound could help regenerate b cell mass and treat type 1
diabetes. In an islet proliferation assay, the compound increased proliferation of primary rat and human islets compared with vehicle. In a mouse model for b cell ablation, the compound increased b cell mass and decreased blood glucose levels compared with vehicle. Next steps include efficacy studies in the nonobese diabetic mice.

SciBX 6(6); doi:10.1038/scibx.2013.139
Published online Feb. 14, 2013

Patent application filed; unlicensed

Shen, W. et al. J. Am. Chem. Soc.; published online Jan. 19, 2013;
doi:10.1021/ja309304m
Contact: Peter G. Schultz, The Scripps Research Institute, La Jolla, Calif.
e-mail:

schultz@scripps.edu
Contact: Richard Glynne, The Genomics Institute of the Novartis Research Foundation, San Diego, Calif.
e-mail:

rglynne@gnf.org