Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

p53

Cell culture and mouse studies suggest reducing dietary serine could help treat p53-deficient cancers. In p53-deficient human colorectal cancer cells, compared with non-p53-deficient cells, serine depletion led to decreased proliferation. In a mouse xenograft model of p53-deficient human colorectal cancer, a serine-depleted diet decreased tumor volumes compared with that seen in non-p53-deficient tumors. Next steps could include evaluating serine depletion in additional models of p53-deficient cancers.

SciBX 6(2); doi:10.1038/scibx.2013.33
Published online Jan. 17, 2013

Patent and licensing status unavailable

Maddocks, O.D.K. et al. Nature; published online Dec. 16, 2012;
doi:10.1038/nature11743
Contact: Karen H. Vousden, The Beatson Institute for Cancer Research, Glasgow, U.K.
e-mail:

k.vousden@beatson.gla.ac.uk