This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact ­information

Neurology

Alzheimer's disease (AD)

Apolipoprotein E (APOE)

Mouse studies suggest mAbs against APOE could help treat AD. In a mouse model of AD, treatment early in life with APOE mAbs led to higher microglial activity and lower levels of b-amyloid (Ab) aggregation in the brain than control mAb treatment. Next steps include testing the mAbs in mice bearing human versions of APOE, including the AD-associated APOE e4 allele.

SciBX 5(49); doi:10.1038/scibx.2012.1290
Published online Dec. 20, 2012

Patent pending; available for licensing

Kim, J. et al. J. Exp. Med.; published online Nov. 5, 2012;
doi:10.1084/jem.20121274
Contact: David M. Holtzman, Washington University in St. Louis School of Medicine, St. Louis, Mo.
e-mail:

holtzman@neuro.wustl.edu