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Alzheimer's disease (AD)

SRSF protein kinase 2 (SRPK2)

Human sample and mouse studies suggest inhibiting SRPK2 signaling could help treat AD. In brain tissue samples from patients with AD, levels of activated SRPK2 were higher in AD-associated pathological structures than surrounding tissue. In a mouse model of AD, small hairpin RNA against Srpk2 in the dentate gyrus of the brain increased memory performance and decreased microtubule-associated protein-t (Mapt; Tau; Ftdp-17) phosphorylation compared with control shRNA. Next steps could include screening for small molecules that could inhibit SRPK2 signaling.

SciBX 5(48); doi:10.1038/scibx.2012.1264
Published online Dec. 13, 2012

Unpatented; licensing status not applicable

Hong, Y. et al. J. Neurosci.; published online Nov. 28, 2012;
Contact: Keqiang Ye, Emory University School of Medicine, Atlanta, Ga.

Contact: Chi Bun Chan, same affiliation as above