Thursday, November 29, 2012
Protein tyrosine phosphatase 1B (PTP-1B; PTPN1)
Cell culture and feline
studies suggest PTP-1B inhibitors could increase the efficacy of interferon
therapies against viral infections. In cultured cells infected with HCV or
vesicular stomatitis virus, type 1 interferon (IFN1)
plus the PTP-1B inhibitor 7-CBNP decreased viral replication
compared with IFN1 alone. In cats with chronic infection of feline
calicivirus, submucosal injection of 7-CBNP decreased inflammation compared
with that seen prior to treatment. Next steps include using 7-CBNP or other
PTP-1B inhibitors in nonmouse models of viral infection, including HIV-related
feline immunodeficiency virus (FIV).
TransTech Pharma Inc.'s PTP-1B
is in Phase II testing to treat diabetes.
Isis Pharmaceuticals Inc.'s ISIS-PTP1bRx,
a PTP-1B antisense oligonucleotide, is in Phase I testing to treat diabetes.
Ohr Pharmaceutical Inc.'s trodusquemine
a small molecule PTP-1B inhibitor, is in Phase I testing for the same
SciBX 5(46); doi:10.1038/scibx.2012.1210
Published online Nov. 29, 2012
Patented; available for
Carbone, C.J. et al.
Proc. Natl. Acad. Sci. USA; published online Nov. 5, 2012;
Contact: Serge Y. Fuchs, University of Pennsylvania, Philadelphia,
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